Selected reading

Extensive pre-clinical & clinical experience

More than four hundred scientific reports have been published on the chemistry, biological properties and clinical performance of the CBAS® technology by groups from all over the world. Below is a selection of papers representative of what has been published throughout the years.

Historic
Basic
Vascular grafts
Extracorporeal circulation - Long term assist
Extracorporeal circulation - Cardiac surgery
Stents
Catheters 

For a complete list of published scientific papers, the latest please download the latest reference list.

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Historic
A NEW NON-THROMBOGENIC SURFACE PREPARED BY SELECTIVE COVALENT BINDING OF HEPARIN VIA A MODIFIED REDUCING TERMINAL RESIDUE
Larm, O. et al., Med. dev., Art. Org., 11:2-3 (1983) 161-173.

AN APPROACH TO ANTITHROMBOSIS BY SURFACE MODIFICATION
Larm, O.; Lins, L. E.; Olsson, P., Progress in Artificial Organs 1986, 313-318.

Basic
ON THE BLOOD COMPATIBILITY OF END-POINT IMMOBILIZED HEPARIN
Olsson, P. et al., J. Biomater. Sci. Polymer Edn., 11:11 (2000) 1261-1273.

HEMOCOMPATIBILITY OF HEPARIN-COATED SURFACES AND THE ROLE OF SELECTIVE PLASMA PROTEIN ADSORPTION
Weber, N. et al., Biomaterials 2002, 23 (2), 429-439

MECHANISM OF COMPLEMENT ACTIVATION DURING EXTRACORPOREAL BLOOD-BIOMATERIAL INTER-ACTION: EFFECTS OF HEPARIN COATED AND UNCOATED SURFACES
Kopp, R. et al., ASAIO J 48:6 (2002) 598-605

Vascular grafts
IMPROVEMENTS IN GORE-TEX® VASCULAR GRAFT PERFORMANCE BY CARMEDA® BIOACTIVE SURFACE HEPARIN IMMOBILIZATION
Begovac, P.C. et al., Eur J Vasc Endovasc Surg 25(2003) 423-437

SMALL CALIBER HEPARIN-COATED e-PTFE GRAFTS REDUCE PLATELET DEPOSITION AND NEOINTIMAL HYPERPLASIA IN A BABOON MODEL
Lin, P. et al., J Vasc Surg 39:6 (2004) 1322-1328

HEPARIN IMMOBILIZATION REDUCES THROMBOGENICITY OF SMALL-CALIBER EXPANDED POLYTETRAFLUOROETHYLENE GRAFTS.
Heyligers, J.M. et al., J Vasc Surg 43:3 (2006) 587-591.

HEPARIN-BONDED ePTFE GRAFTS COMPARED WITH VEIN GRAFTS IN FEMOROPOPLITEAL AND FEMOROCRURAL BYPASSES: 1- AND 2-YEAR RESULTS

Daenens, K. et al., J Vasc Surg 2009, 49, (5), 1210-1216.

HEPARIN-BONDED EXPANDED POLYTETRAFLUOROETHYLENE GRAFT FOR INFRAGENICULAR BYPASS: FIVE-YEAR RESULTS

Lösel-Sadée, H., J Cardiovasc Surg, 2009, 50, (3), 339-343.

 

HEPARIN BONDED HEMODIALYSIS E-PTFE GRAFTS RESULT IN 20% CLOT FREE SURVIVAL BENEFIT
Davidson, I., J Vasc Access 2009, 10, (3), 153-156.

Extracorporeal circulation - Long term assist
SUPERIOR HEMODYNAMICS IN LEFT HEART BYPASS WITHOUT SYSTEMIC HEPARINIZATION
von Segesser, L.K. et al., J. Cardio-thorac. Surg., 4 (1990) 384-389.

HEPARIN COATED VERSUS NON-COATED SURFACES FOR EXTRACORPOREAL CIRCULATIONS
Mottaghy, K. et al., 17th Congr. ESAO, Bologna, Italy, Int. J. Artif. Organs., 14:11 (1990) 721-728.

EXTRACORPOREAL CARBON DIOXIDE REMOVAL PERFORMED WITH SURFACE-HEPARINIZED EQUIPMENT IN PATIENTS WITH ARDS
Bindslev, L. et al., Acta Anaesthesiol Scand Suppl 1991, 95, 125-30; discussion 130-131.

BIOCOMPATIBLE CIRCUITS: AN ADJUNCT TO NON-CARDIAC EXTRACORPOREAL CARDIOPULMONARY SUPPORT
Bennett, J. et al., J Extra Corpor Technol 1992, 24, 6-11.

PROGRESS IN VENO-VENOUS LONG-TERM BYPASS TECHNIQUES FOR THE TREATMENT OF ARDS
Knoch, M. et al., J. Artif. Org., 15:2 (1992) 103-108.

EXTRACORPOREAL MEMBRANE OXYGENATION: PRELIMINARY RESULTS IN PATIENTS WITH POSTCARDIOTOMY CARDIOGENIC SHOCK
Magovern, G.J. et al., Ann. Thorac. Surg., 57 (1994) 1462-1471.

Extracorporeal circulation - Cardiac surgery
BIOCOMPATIBILITY OF EXTRACORPOREAL CIRCULATION: IN VITRO COMPARISON OF HEPARIN COATED AND UNCOATED OXYGENATOR CIRCUITS
Videm, V. et al., Cardiovasc. Surg., 101 (1991) 654-660.

CLINICAL EFFECTS OF THE HEPARIN COATED SURFACE IN CARDIOPULMONARY BYPASS
Svenmarker, S. et al., J. Carido-thorac. Surg., 11 (1997) 957-964.

A CLOSED PERFUSION SYSTEM WITH HEPARIN COATING AND CENTRIFUGAL PUMP IMPROVES CARDIO-PULMONARY BYPASS BIOCOMPATIBILITY IN ELDERLY PATIENTS
Lindholm, L. et al., Ann Thorac Surg 78:6 (2004) 2131

REDUCING HEMOSTATIC ACTIVATION DURING CARDIOPULMONARY BYPASS: A COMBINED APPROACH
Eisses, M. J. et al., Anesth Analg 2004, 98, (5), 1208-1216.

HEPARINIZED CARDIOPULMONARY BYPASS CIRCUITS AND LOW SYSTEMIC ANTICOAGULATION: AN ANALYSIS OF NEARLY 6000 PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING.
Ovrum E. et al., J Thorac Cardiovasc Surg. 2010 Aug 13.

DECREASED BLOOD LOSS FOLLOWING CARDIOPULMONARY BYPASS USING HEPARIN-COATED CIRCUITS AND 50% REDUCTION OF HEPARIN DOSE
Borowiec, J. et al., J Thorac Cardiovasc Surg 1992, 26, (3), 177-185.

CHANGES IN PLATELET, GRANULOCYTE, AND COMPLEMENT ACTIVATION DURING CARDIOPULMONARY BYPASS USING HEPARIN-COATED EQUIPMENT
Fukutomi, M. et al., Artif Organs 1996, 20, (7), 767-776.

Stents
REDUCTION IN THROMBOTIC EVENTS WITH HEPARIN-COATED PALMAZ-SCHATZ STENTS IN NORMAL PORCINE CORONARY ARTERIES
Hårdhammar, P.A. et al., Circulation, 93 (1996) 423-430.

HEPARIN-COATED BALLOON-EXPANDABLE STENT REDUCES INTIMAL HYPERPLASIA IN THE ILIAC ARTERY IN BABOONS
Lin, P. H. et al., J Vasc Interv Radiol 2003, 14, (5), 603-611.

RANDOMISED COMPARISON OF IMPLANTATION OF HEPARIN-COATED STENTS WITH BALLOON ANGIOPLASTY IN SELECTED PATIENTS WITH CORONARY ARTERY DISEASE (BENESTENT II). Serruys, P. W. et al., Lancet 1998, 352, (9129), 673-681.

CORONARY ANGIOPLASTY WITH OR WITHOUT STENT IMPLANTATION FOR ACUTE MYOCARDIAL INFARCTION. STENT PRIMARY ANGIOPLASTY IN MYOCARDIAL INFARCTION STUDY GROUP
Grines, C. L. et al., N Engl J Med 1999, 341, (26), 1949-1956.

IN VIVO MODEL OF INTRACRANIAL STENT IMPLANTATION: A PILOT STUDY TO EXAMINE THE HISTOLOGI-CAL RESPONSE OF CEREBRAL VESSELS AFTER RANDOMIZED IMPLANTATION OF HEPARIN-COATED AND UNCOATED ENDOLUMINAL STENTS IN A BLINDED FASHION
Levy, E.I. et al., J Neurosurg 98:3 (2003) 544-553

AN INTERNET-BASED REGISTRY EXAMINING THE EFFICACY OF HEPARIN COATING IN PATIENTS UNDERGOING CORONARY STENT IMPLANTATION
Mehran, R. et al., Am Heart J JT - American Heart Journal. 2005, 150, (6), 1171-1176.

CORONARY INTERVENTION WITH A HEPARIN-COATED STENT AND ASPIRIN ONLY
Ruygrok, P.N. et al., J Invasive Cardiol 15:8 (2003) 439-441

REDUCTION OF SUBACUTE STENT THROMBOSIS (SAT) USING HEPARIN-COATED STENTS IN A LARGE SCALE, REAL WORLD REGISTRY
Gupta, V. et al., J Invasive Surg 16:6 (2004) 304-310

Catheters
SURFACE HEPARINIZATION OF CENTRAL VENOUS CATHETERS REDUCES MICROBIAL COLONIZATION IN VITRO AND IN VIVO: RESULTS FROM A PROSPECTIVE, RANDOMIZED TRIAL
Appelgren, P. et al., Crit. Care Med., 24:9 (1996) 1482-1489.

EFFECT OF COVALENTLY BOUND HEPARIN COATING ON PATENCY AND BIOCOMPATIBILITY OF LONG-TERM INDWELLING CATHETERS IN THE RAT JUGULAR VEIN
Foley, P. et al., Comparative Medicine 52 (2002) 243-248

DOES HEPARIN COATING IMPROVE PATENCY OR REDUCE INFECTION OF TUNNELED DIALYSIS CATHETERS?
Jain, G.et al., Clin J Am Soc Nephrol., 2009,4, (11), 1787-1790.

 

For a complete list of publications, please download:

CBAS reference list June 2010 (PDF 150k)